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Dr. Peyton Driscoll serves as one of the medical examiners for the New York Police Department. She is originally from London, England. Though she first appears on screen in episode 301 (People With Money), it is indicated that she has worked in New York for some time longer. She has been a colleague of both Doctors Sid Hammerback and Sheldon Hawkes for a number of years and considers herself "a little protective"(episode 307, "Murder Sings the Blues").

Peyton is hurt, though not seriously, when she is slammed against the coroner's van by two men outside the lab, who then steal the body of a man that the MEs had just retrieved from a crime scene. The body is later fished out of the Hudson River, still in the body bag. To Peyton's shock, the man is alive, though in a permanent vegetative state. She is distressed about how she could have pronounced the man dead in the first place, but is reassured, by Mac, that her pronouncement was perfectly reasonable under the circumstances; it is eventually determined that the victim had been intentionally placed in a state of hibernation by a combination of chemicals administered to him.

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